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SPICE: Analysis of enadenotucirev plus nivolumab in metastatic colorectal cancer patients during the dose escalation phase

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Published: 04.10.19
Views: 774
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Prof Marwan Fakih - City of Hope National Medical Center, Duarte, USA

Prof Marwan Fakih speaks to ecancer at ESMO 2019 in Barcelona about the results from the phase I SPICE study, which investigated the combination of enadenotucirev plus nivolumab in metastatic tumours of epithelial origin.

He presents the latest results obtained from this study, in which the patients with metastatic colorectal cancer lived longer than expected and experienced a median overall survival of more than 12 months.

Prof Fakih believes there is more to be learned as prior studies have suggested enadenotucirev increases T-cell infiltration and may be synergistic to the action of some checkpoint inhibitors. However, biomarkers for this response are yet to be determined, along with the underlying mechanisms of synergy and resistance.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

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