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AMG 510: A novel molecule targeting KRAS G12C mutant solid tumours

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Published: 04.10.19
Views: 603
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Prof Marwan Fakih - City of Hope National Medical Center, Duarte, USA

Prof Marwan Fakih speaks to ecancer at ESMO 2019 in Barcelona about the phase I study of AMG 510, which a novel agent that targets solid tumours with a KRAS G12C mutation. 

He presents the updated safety data in patients with predominately non-small-cell lung cancer (NSCLC) and colorectal cancer.

Prof Fakih also reports that approximately half of the NSCLC patients had an objective response and 79 percent of colorectal cancer patients had disease control.

He emphasises that this agent displays clear activity and is robust in NSCLC. Combinations with AMG 510 are now being explored, including immunotherapy and MEK inhibitors.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

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