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Targeted therapies in prostate cancer: Recent advances presented at ESMO 2019

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Published: 30.09.19
Views: 2826

Dr Eleni Efstathiou, Prof Noel Clarke, Dr Elena Castro, Prof Matthew Smith

Dr Eleni Efstathiou (MD Anderson Cancer Center, Houston, USA), Prof Noel Clarke (The Christie NHS Foundation Trust, Manchester, UK), Dr Elena Castro (Spanish National Cancer Research Center, Madrid, Spain) and Prof Matthew Smith (Massachusetts General Hospital Cancer Center, Boston, USA) discuss the key developments presented at ESMO 2019 on targeted therapies in prostate cancer.

The panel discuss the latest data from the STAMPEDE trial and the use of docetaxel in high-volume disease versus low-volume disease in metastatic de-novo and hormone naïve prostate cancer.

Prof Smith also gives an overview of the STAMPEDE study and the recent developments presented from this trial at ESMO 2019.

The panel conclude by discussing the PROFOUND study, using olaparib in the treatment of patients with metastatic castration-resistant prostate cancer who harbour homologous recombination repair gene mutations. However, identifying these patients with DNA mismatch repair mutations, not just BRCA mutations remains a challenge.

This programme has been supported by an unrestricted educational grant from Janssen Pharmaceutica (A Johnson & Johnson Company).

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