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Phase III results of PROSPECT study for metastatic, castration-resistant prostate cancer

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Published: 04.06.18
Views: 3556

Dr James Gulley - Center for Cancer Research, Washington, USA

Dr Gulley speaks with ecancer at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting about the results of the PROSPECT study.

This is a randomised phase III trial of PROSTVAC-V/F in men with asymptomatic or minimally symptomatic metastatic, castration-resistant prostate cancer. PROSTVAC-V/F is a PSA-targeted, poxvirus-based cancer vaccine using a heterologous prime-boost regimen comprising a recombinant vaccinia vector prime followed by 6 booster doses with the recombinant fowlpox vector.

PROSPECT failed to confirm an overall survival benefit observed in a prior phase II study. He highlights the potential to combine with other checkpoint inhibitors in future trials, based on immune infiltrate data.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

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