Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 13 972 / https://doi.org/10.3332/ecancer.2019.972

Case Report

Common B-cell acute lymphoblastic leukaemia in a 70-year-old woman presenting 2 years after carboplatin-taxane radiotherapy for endometrial cancer

Therapy-related acute lymphoblastic leukaemia (t-ALL) is a poorly defined entity and is not featured in the World Health Organization classification as a distinct clinical entity from acute lymphoblastic leukaemia (ALL), thus differing from therapy-related acute myeloid leukaemia and myelodysplasia. We present a case of t-ALL occurring 18 months after treatment for metastatic endometrial cancer with a regimen of carboplatin, paclitaxel and radiotherapy. The patient presented with severe pancytopenia and diagnosed with common-B ALL, and the cytogenetic analysis showed a previously unreported deletion in chromosome 19 (q13.1) in 100% of the blast cells. The patient declined further therapy and died 1 month later. This rare but serious side effect of chemo-radiotherapy should be considered when deciding on treatment options for gynaecological cancers.

Keywords: therapy-related acute lymphoblastic leukaemia, endometrial cancer, carboplatin, paclitaxel

Loading Article Metrics ... Please wait

Related articles

Research: Histopathologic patterns of cutaneous malignancies in individuals with oculocutaneous albinism in Anambra state, Nigeria: a paradigm swing?

Abstract | Full Article | PDF Published: 20 Feb 2020 / https://doi.org/10.3332/ecancer.2020.1013

Case Report: Multiple myeloma with concurrent immune thrombocytopenic purpura

Abstract | Full Article | PDF Published: 20 Feb 2020 / https://doi.org/10.3332/ecancer.2020.1012

Case Report: The development of T-cell malignancies in patients with pre-existing myeloproliferative neoplasms: a report of three cases

Abstract | Full Article | PDF Published: 17 Feb 2020 / https://doi.org/10.3332/ecancer.2020.1011

Case Report: Slowly developing toxic epidermal necrolysis-like reaction associated with pemetrexed and carboplatin

Abstract | Full Article | PDF Published: 13 Feb 2020 / https://doi.org/10.3332/ecancer.2020.1010

Case Report: Multiple malignant transformations of an ovarian mature cystic teratoma

Abstract | Full Article | PDF Published: 04 Feb 2020 / https://doi.org/10.3332/ecancer.2020.1009



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation