Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 13 956 / https://doi.org/10.3332/ecancer.2019.956

Research

Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas

Purpose: Evidence suggests a correlation of subventricular zone (SVZ) irradiation on survival. Most of the data have been analysed in glioblastoma patients. The aim of this study is to analyse the dose to the subventricular and periventricular zone and its outcomes in anaplastic gliomas.

Materials and methods: A retrospective analysis of patients with anaplastic gliomas were admitted for post-chemoradiation from January 2010 to June 2016 was done from treatment records. SVZ was contoured as 5 mm expansion along the lateral margin of the lateral ventricles, and PVZ was contoured as 5 mm lateral expansion adjacent to ventricles. Dosimetric data were collected from the treatment planning system.

Results: Ninety-five patients were included in the analysis. The median age was 35 years. Two- and five-year overall survival (OS) for the entire group was 84% and 54.2%, respectively. Two- and five-year progression-free survival (PFS) was 79.8% and 50.6%, respectively. Patients receiving <54 Gy to the i/l SVZ showed a significantly better PFS and OS. 5-Year OS was 72.6% in this group compared to 37% for the group receiving ≥54 Gy (p = 0.01). Five-year PFS was 69.9% in this group compared to 31.9% for the group receiving ≥54 Gy (p = 0.02). However, this was not significant in multivariate analysis.

Conclusion: Increased dose to the ipsilateral SVZ does not correlate with improved survival in anaplastic gliomas. There is conflicting evidence regarding the benefit of irradiating the stem cell zones. Future studies should focus on optimizing doses to these areas to reduce detriment in neurocognition.

Keywords: subventricular zone, anaplastic gliomas, neurocognition, periventricular zone

Loading Article Metrics ... Please wait

Related articles

Case Report: Successful osimertinib rechallenge following drug-induced pneumonitis after previous anti-PDL1 exposure

Abstract | Full Article | PDF Published: 21 Oct 2019 / https://doi.org/10.3332/ecancer.2019.970

Case Report: Scalp and skull bone metastasis in cervical carcinoma—a rare entity

Abstract | Full Article | PDF | Español Published: 17 Oct 2019 / https://doi.org/10.3332/ecancer.2019.969

Research: Laparoscopic colectomies associated with decreased retrieval of 12 or more lymph nodes compared to open in elective colon cancer surgery

Abstract | Full Article | PDF Published: 14 Oct 2019 / https://doi.org/10.3332/ecancer.2019.968

Clinical Study: Complete metastasectomy in renal cell carcinoma: a propensity-score matched by the International Metastatic RCC Database Consortium prognostic model

Abstract | Full Article | PDF Published: 14 Oct 2019 / https://doi.org/10.3332/ecancer.2019.967

Review: Effective interventions to improve the health literacy of cancer patients

Abstract | Full Article | PDF | Español Published: 10 Oct 2019 / https://doi.org/10.3332/ecancer.2019.966



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation