Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 12 864 / https://doi.org/10.3332/ecancer.2018.864

Special Issue

The implementation of omics technologies in cancer microbiome research

Whilst the interplay between host genetics and the environment plays a pivotal role in the aetiopathogenesis of cancer, there are other key contributors of importance as well. One such factor of central and growing interest is the contribution of the microbiota to cancer. Even though the field is only a few years old, investigation of the ‘cancer microbiome’ has already led to major advances in knowledge of the basic biology of cancer risk and progression, opened novel avenues for biomarkers and diagnostics, and given a better understanding of mechanisms underlying response to therapy. Recent developments in microbial DNA sequencing techniques (and the bioinformatics required for analysis of these datasets) have allowed much more in-depth profiling of the structure of microbial communities than was previously possible. However, for more complete assessment of the functional implications of microbial changes, there is a growing recognition of the importance of the integration of microbial profiling with other omics modalities, with metabonomics (metabolite profiling) and proteomics (protein profiling) both gaining particular recent attention. In this review, we give an overview of some of the key scientific techniques being used to unravel the role of the cancer microbiome. We have aimed to highlight practical aspects related to sample collection and preparation, choice of the modality of analysis, and examples of where different omics technologies have been complementary to each other to highlight the significance of the cancer microbiome.

Keywords: microbiome, metataxonomics, metagenomics, metabonomics, metaproteomics

Loading Article Metrics ... Please wait

Related articles

Conference Report: Cancer in pregnancy: an association to make one shiver—highlights from ‘Cancer in pregnancy: 15 years after’, 10–11 October 2019, Milan, Italy

Abstract | Full Article | PDF Published: 03 Dec 2019 / https://doi.org/10.3332/ecancer.2019.981

Review: Advances in pain management for older patients with cancer

Abstract | Full Article | PDF Published: 03 Dec 2019 / https://doi.org/10.3332/ecancer.2019.980

Case Report: Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery

Abstract | Full Article | PDF Published: 26 Nov 2019 / https://doi.org/10.3332/ecancer.2019.979

Research: Awareness of human papilloma virus and cervical cancer prevention among Cypriot female healthcare workers

Abstract | Full Article | PDF Published: 20 Nov 2019 / https://doi.org/10.3332/ecancer.2019.978

Case Report: Case report of a 65-year-old man with biatrial metastatic localisation from poorly differentiated cutaneous squamous cell carcinoma

Abstract | Full Article | PDF Published: 19 Nov 2019 / https://doi.org/10.3332/ecancer.2019.977



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation