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AACR 2016 /
Targeted therapy shows continued promise in patients whose tumours had NTRK gene fusions

16th - 20th Apr 2016

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Published: 29.04.16
Views: 1848

Dr David Hong - University of Texas MD Anderson Cancer Center, Houston, USA

Dr David Hong speaks with ecancertv at AACR 2016 with updated results targeting TRK fusions with LOXO101.

NTRK, normally associated with the sense of touch, can fuse and become oncogenic in a variety of tumour histologies.

LOXO101 is described as the first selective inhibitor of TRKa, b and c, compared to the more generalised entrectinib, which Dr Hong reports as assuring greater specificity and thus lower offtarget effects.

A Phase II trial is ongoing.

For more on Trk fusions, you can watch an interview with Dr Alexander Drilon about a entrectinib, a TRK targeted therapy.

Previous conferences: highlights

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation