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AACR 2016 /
Metastasis intiation mediated by thrombospondin 2

16th - 20th Apr 2016

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Published: 27.04.16
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Dr Ilaria Malanchi - Crick Institute, London, UK

Dr Ilaria Malanchi speaks with ecancertv at AACR 2016 about her research into immune response to metastasis.

She describes how metastatic success of cancer cells can be attributed to Thrombospondin 2 (THBS2), a factor triggering the development of a metastatic niche.

While tumour detection by a host immune system can illicit a systemic response, metastatic spread to other tissues results in a leukotriene-mediated inflammatory response that in turn accelerates infiltration further.

Dr Malanchi describes her research to block this inflammatory pathway using medicine currently available for asthma, and looks forwards to the development of a comprehensive THBS2 strategy. 

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation