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NCRI 2013 /
Polygenic susceptibility: What might it tell us?

3rd - 6th Nov 2013

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Published: 14.11.13
Views: 2992

Sir Bruce Ponder - University of Cambridge, UK

Prof Ponder talks to ecancertv at the UK's National Cancer Research Institute ( NCRI ) 2013 meeting where he received the Lifetime Achievement award.

Prof Ponder's first major success in genetics was the linkage of medullary thyroid cancer to chromosome 10, which led to a test for genetic susceptibility to this rare disease.

In the late 1980s he moved on to study breast cancer; the international consortium he established  in breast cancer genetics led directly to the discovery of BRCA1 and BRCA2.

Later still he was involved in the first genome-wide association scans (GWAS).

Results from these, however, have been disappointing: for example, even with GWAS we have been able to explain less than 20% of the genetic variation in breast cancer risk.

Ponder ended his plenary lecture by suggesting that combining genes into networks might help explain some of this missing heritability of breast cancer.

Previous conferences: highlights

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation