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ESMO 21st World Congress on Gastrointestinal Cancer /
Latest results from KEYNOTE-181: Pembrolizumab versus chemotherapy as a second-line therapy for advanced oesophageal cancer

3rd - 7th Jul 2019

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Published: 15.07.19
Views: 879

Prof Jean-Philippe Metges - Centre Hospitalier Régional et Universitaire de Brest, Brest, France

Prof Jean-Philippe Metges speaks to ecancer at ESMO 21st World Congress on Gastrointestinal Cancer about the final results from the KEYNOTE-181 study, in which patients with advanced oesophageal cancer were administered pembrolizumab or chemotherapy as a second-line therapy.

He describes the design of the trial, including the patient population included in the trial and the outcomes assessed.

Prof Metges states that overall survival was improved in patients with adenocarcinoma and squamous cell carcinoma when administered pembrolizumab. Grade 3 - 5 toxicities and patient quality of life were also improved with pembrolizumab. However, no improvement was seen in progression-free survival.

He concludes by emphasising that this could be a new treatment option for patients with adenocarcinoma and squamous cell carcinoma due to the promising results this phase III trial has generated. 
 

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European Cancer Organisation European Institute of Oncology

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ecancer Global Foundation