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ASCO 2019 /
Mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2 mutated metastatic breast cancer

31st May - 4th Jun 2019

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Published: 11.06.19
Views: 2438

Dr Adrienne Waks - Dana-Farber Cancer Institute, Boston, USA

Dr Adrienne Waks speaks to ecancer at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting about the mechanisms of resistance to platinum-based chemotherapy or PARP inhibitors in patients with BRCA1/2 mutated, metastatic breast cancer.

Dr Waks explains the preliminary findings of this study, in which 50 percent of patients acquired resistance as their tumours were no longer a BRCA1/2 mutant.

The protein RAD51 was also investigated as a potential biomarker, to determine the potency of BRCA1/2.

Dr Waks discusses the feasibility of implementing these techniques in the clinic, along with further work that will need to be carried out.

This programme has been supported by an unrestricted educational grant from Pfizer.

Previous conferences: highlights

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation