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AACR 2019 /
Evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with HPV-associated malignancies

29th Mar - 3rd Apr 2019

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Published: 15.04.19
Views: 1137
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Dr James Gulley - National Cancer Institute, Bethesda, USA

Dr James Gulley speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about a study looking at M7824 (a bifunctional fusion protein targeting TGF-β and PD-L1) in patients with HPV-associated malignancies.

Dr Gulley reports patients with HPV-associated malignancies saw around a 35% response rate and patients with HPV-confirmed malignancies seeing closer to a 40% response rate.

He also points to a 12 month overall survival of above 50% and that response was maintained in 11 out of 15 patients suggesting that there is really good activity in these patients.

 

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Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation